What is a Heartworm?

Heartworm (Dirofilaria immitis) is a fairly large worm - up to 14 inches long - that, in adulthood, lives in the heart and pulmonary arteries of an infected dog. Dogs and Cats acquire this infection through mosquito bites as mosquitoes readily drink larval heartworms from infected dogs or cats, to nurture their development, and ultimately carry them to new pets.

Early Infection

The migration of the young worm once it enters the pet’s body is a long one: a journey of five to seven months. In that time, the worm is growing, maturing, and preparing to mate. While all this is happening, nothing is happening to the pet and no one knows an invasion has taken place.

Worms in the Pulmonary Arteries

At the end of this long migration, the worm has reached its destination: a pulmonary artery. The worm is large and takes up a lot of space in the artery. The pet’s immune system recognizes foreign proteins present and launches an attack but the immune system is designed to work against smaller invaders such as bacteria or viruses. The heartworm is too big to be killed effectively this way and the result is inflammation and thickening in the arteries.

Blood flow becomes turbulent and the tendency to form abnormal clots is increased. Adding to this unpleasant mix is a bacterium called Wolbachia pipientis, which normally lives inside the heartworm but is released in large numbers every time the heartworm molts to a new developmental stage, gives birth to its young, or dies. These bacteria contribute heavily to the resultant inflammation occurring in the pulmonary arteries and lung tissue itself. Blood vessels get stiff and cannot operate normally, creating a high-resistance area that the heart must pump through.

The inflammation calls in numerous immune cells, which in turn generate even more inflammation as they attempt to destroy a parasite as relatively large as a heartworm. The lung itself becomes inflamed and in time becomes scarred, creating an even larger high-resistance area for the heart to pump through.

If there are many worms, the problem is multiplied. Some arteries may actually be obstructed by the number of worms. This leaves areas of the lung unable to receive circulation, which means these areas cannot participate in oxygen exchange.

Dying Worms

As if that wasn't bad enough, the real damage comes from worms that have died in place. The dead body of the heartworm breaks apart and is carried through the vasculature of the lung until it lodges somewhere and obstructs blood flow. The arteries that are supposed to form delicate branches, branching tinier and tinier, are now blunted and closed off, similar to a tree branch broken off close to the tree trunk. As above, this leaves more areas of lung blocked off and unable to receive blood and participate in oxygen exchange.

Scarring

All the inflammation generated by the worms as well as the inflammation generated by the areas of lung that aren't receiving proper circulation ultimately translates into scarring in the lung vasculature. Scarring and fibrosis makes it difficult for the heart to pump blood through the lung effectively. There is a point where the heart is not strong enough to pump blood through all the narrowed, stiff damaged capillary beds. Right sided heart failure ensues.

How Many Worms are too Many?

In naturally infected dogs, the number or worms does not correlate to severity of disease, even in dogs of the same size. The main reason for this is activity level. The factors that come into play to create severity of disease are: the dog’s activity level (the more active the dog, the fewer worms are needed to create disease), the size of the dog, and the number of worms the dog has. The infected dog that sits around at home may appear relatively normal but once some exercise or even anxiety puts more demand on his heart, symptoms erupt. 

In cats, usually just 1 adult worm is enough to obstruct their heart and cause respiratory issues such as coughs, or weezing.

Symptoms of Heartworm Disease

  • Coughing
  • Shortness of breath/panting
  • Easy tiring/intolerance of exercise
  • Fluid accumulation in the abdomen or chest
  • Nose bleeds
  • Sudden death

Obviously, not all of these things necessarily occur in the same dog or cat, nor is there necessarily a progression. An infected pet may have no symptoms at all or may develop any of the signs on the list at any time.

Chronic Immune Stimulation and Glomerular Disease

When a pet goes without treatment for heartworm infection, its immune system becomes chronically stimulated. Antibodies, which are not only important tools of the immune system but are inflammatory proteins, are produced in high amounts all the time. These antibodies can cause a lot of trouble by dropping into the delicate membranes of the eye, blood vessels, joints, and kidney. Antibodies stuck in these areas, call in inflammatory cells and damage these delicate membranes, thus setting up tremendous tissue damage and pain. In particular, heartworm infection is a cause of a type of kidney inflammation called glomerular disease. Fortunately, this inflammation and its consequences can frequently be resolved by treating heartworm infection.

Caval Syndrome: A Special Catastrophe

Caval syndrome is an especially disastrous form of heartworm disease. Here, there are so many worms (around 100) that the entire right side of the heart is filled with worms and they are backing out into the large veins that feed the right side of the heart. Usually there have been no signs of heart disease prior to the collapse, shock, and red blood cell destruction associated with this syndrome. Death usually occurs within one to two days and the only effective treatment is to open the dog's jugular vein and physically remove the worms with a clamp. If enough worms can be removed to re-establish blood flow, the dog may survive.

Detection

Heartworms can be detected by running a simple blood test usually 1 drop or 3 drops depending on the type of test. The results are often ready in 15 min. And are available for both dogs and cats and should be done annually. We recommend running a heartworm test prior to starting your pet on a preventative.

Prevention

Heartworm preventive medications are used to kill larval heartworms that have managed to gain access to the dog’s body. At this point, the products available are intended for monthly use, with the exception of Proheart6 which is a biannual injection, or Proheart12 which is a yearly injection. This means each time they are given they kill all the heartworm larvae (stage L3 and L4) that have accumulated in the past month.

There are currently many choices, topical, oral and even injectable. These are the products that we carry.

  • Heartgard Plus - Oral monthly chewable. Also treats roundworms and hookworms.
  • Interceptor Plus - Oral monthly chewable. Also treats roundworms, hookworms, whipworms, and tapeworms. Revolution Plus - Monthly topical treatment. Also treats fleas, sarcoptic mange, ear mites, ticks, roundworms and hookworms. Used for cats.
  • Proheart 6 - An injection lasting 6 months. Also treats hookworms.
  • Proheart 12 - A yearly injection. Also treats hookworms.
  • Nexgard Plus - Dogs - Oral monthly chewable. Also treats fleas.
  • Nexgard Combo - Cats - monthly topical.

Ask us about what heartworm prevention is appropriate for your dog. Cat’s can get heartworm disease too. This is not just a dog problem but a cat one too.